Bioequivalence and Bioavailability Forum

Thanks for the forum and the informative data sharing..

We are dealing with one of the endogenous compound. LOQ is high nearly 1 ng/mL where as Cmax itself is around 8-9ng/mL

We asked many BE labs in India and we couldn't get a bioanalytical method which is sensitive to the acceptable extent.

One of the lab offered a method with 0.25 ng/mL with some interferences.
Is this acceptable (i.e with interferences)? If it is acceptable, do we need to do any corrections?

Does using internal standard help to any extent?

Thanks again for HELMUT for having such a fabulous Forum..

Regards,
Bharathi