Bioequivalence and Bioavailability Forum

+partial replicate [Study Assessment]

posted by Helmut – Vienna, Austria, 2012-10-11 19:53 (5004 d 20:39 ago) – Posting: # 9394
Views: 12,309

Dear Detlew & Dan

❝ PowerTOST (exact via Owen's Q-function) gives you for your above settings:

❝ Design N power

❝ 2x2x2 20 0.834680

❝ 2x2x3 14 0.817926

❝ 2x2x4 10 0.843312

Nitpicking: “2×2×3” is the full replicate 3-period design (TRT|RTR). The fashionable partial replicate (TRR|RTR|RRT) would give:
2x3x3 15 0.844011 – since the sample size has to be a multiple of 3.

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Helmut Schütz

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Complete thread:

Failure of BE in fasting studies ABE1580 2012-10-09 15:42
- Failure of BE in fasting studies drgunasakaran1 2012-10-09 20:07
  - Failure of BE in fasting studies cakhatri 2012-10-10 07:34
    - Failure of BE in fasting studies Dr_Dan 2012-10-10 13:09
    - Different designs: why not? Helmut 2012-10-10 13:48
      - Different designs: why not? cakhatri 2012-10-12 10:42
    - Failure of BE in fasting studies drgunasakaran1 2012-10-10 19:14
      - Failure of BE in fasting studies ABE1580 2012-10-11 06:10
  - Failure of BE in fasting studies drsinghs 2012-10-11 09:28
    - Failure of BE in fasting studies Dr_Dan 2012-10-11 11:43
      - 1–β not necessarily = Δ Helmut 2012-10-11 13:05
      - Sample size d_labes 2012-10-11 13:10
        
        +partial replicateHelmut 2012-10-11 17:53

+partial replicate [Study As­sess­ment]

Complete thread:

+partial replicate [Study Assessment]