Bioequivalence and Bioavailability Forum

Enterohepatic recirculation [Study Assessment]

posted by cakhatri – India, 2012-09-11 08:26 (5031 d 11:00 ago) – Posting: # 9172
Views: 10,854

Dear Helmut,

Thanks for your suggestion. The situation is

We had earlier carried out a pilot study and there was no such observation.
The last sample is at 72hrs, the observation of double absorption is seen from 16th hour onwards (Cmax) and in some cases 24hrs also (Cmax) and therefore AUC estimates are not reliable

If there are other ways of handling this situation please advice

Regards
Chirag

Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Jaime]

Complete thread:

high concentration in the elimination phase-Metaxalone cakhatri 2012-09-07 05:58
- high concentration in the elimination phase-Metaxalone jag009 2012-09-07 23:20
  - high concentration in the elimination phase-Metaxalone cakhatri 2012-09-08 06:08
    - Enterohepatic recirculation Helmut 2012-09-08 12:29
      - Enterohepatic recirculationcakhatri 2012-09-11 06:26
        
        Enterohepatic recirculation jag009 2012-09-13 19:56
    - high concentration in the elimination phase-Metaxalone jag009 2012-09-10 22:30
      - high concentration in the elimination phase-Metaxalone cakhatri 2012-09-11 06:29
        
        high concentration in the elimination phase-Metaxalone Chiku 2012-09-14 06:30

Enterohepatic recirculation [Study As­sess­ment]

Complete thread:

Enterohepatic recirculation [Study Assessment]