Log in
RegisterEnterohepatic recirculation [Study Assessment]
posted by Helmut 
– Vienna, Austria, 2012-09-08 14:29 (5044 d 10:56 ago) – Posting: # 9164
Views: 11,244
Hi Chirag!
Generally enterohepatic recirculation is a property of the drug – not of the formulation. In BE we are only interested in the latter. If you suspect recirculation you can opt for AUC72 thus avoiding potential problems in estimating the elimination phase (which might be your case). Since the study is already finished you can only discuss the results and concentrate on AUC72 rather than on AUCt/AUC∞.
❝ […] advise what measures to take to avoid such situation
Generally enterohepatic recirculation is a property of the drug – not of the formulation. In BE we are only interested in the latter. If you suspect recirculation you can opt for AUC72 thus avoiding potential problems in estimating the elimination phase (which might be your case). Since the study is already finished you can only discuss the results and concentrate on AUC72 rather than on AUCt/AUC∞.
—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!![[image]](https://static.bebac.at/pics/Blue_and_yellow_ribbon_UA.png)
Helmut Schütz
![[image]](https://static.bebac.at/img/CC by.png)
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- high concentration in the elimination phase-Metaxalone cakhatri 2012-09-07 05:58
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- high concentration in the elimination phase-Metaxalone jag009 2012-09-07 23:20
- high concentration in the elimination phase-Metaxalone cakhatri 2012-09-08 06:08
- Enterohepatic recirculationHelmut 2012-09-08 12:29
- Enterohepatic recirculation cakhatri 2012-09-11 06:26
- Enterohepatic recirculation jag009 2012-09-13 19:56
- Enterohepatic recirculation cakhatri 2012-09-11 06:26
- high concentration in the elimination phase-Metaxalone jag009 2012-09-10 22:30
- high concentration in the elimination phase-Metaxalone cakhatri 2012-09-11 06:29
- high concentration in the elimination phase-Metaxalone Chiku 2012-09-14 06:30
- high concentration in the elimination phase-Metaxalone cakhatri 2012-09-11 06:29
- Enterohepatic recirculationHelmut 2012-09-08 12:29
- high concentration in the elimination phase-Metaxalone cakhatri 2012-09-08 06:08
- high concentration in the elimination phase-Metaxalone jag009 2012-09-07 23:20
Ing. Helmut Schütz