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Hello LB,
Yes, this spells trouble. Highly variable drug 'in some patients'. Or highly variable patients among your study population. I think this is where recruitment principles could help you in the future - no guarantees though. I can't imagine a solution in the concrete situation, especially not when non-parametrics are discouraged.
❝ But that is not the problem of formulation as all others (65 volunteer out of 66) gave normal results in the range of 80-125% TR ratio (with min of 34% and max of 244%) and only one was acting weird.
❝ If such is the case, even after reformulation same volunteer or someone of the same category 
could be there to kill your study!!
Yes, this spells trouble. Highly variable drug 'in some patients'. Or highly variable patients among your study population. I think this is where recruitment principles could help you in the future - no guarantees though. I can't imagine a solution in the concrete situation, especially not when non-parametrics are discouraged.
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Pass or fail!
ElMaestro
Pass or fail!
ElMaestro
Complete thread:
- Redosing study… H.Patel 2011-06-15 16:28
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Redosing study… swapnil.kuche 2011-06-16 08:35
- Redosing study… Dr_Dan 2011-06-16 12:37
- Redosing study… Helmut 2011-06-16 12:52
- Redosing study… GSTATS 2011-06-16 16:12
- Redosing study… luvblooms 2011-06-17 06:34
- Redosing study… ElMaestro 2011-06-17 09:16
- Redosing study… luvblooms 2011-06-17 12:50
- Redosing study…ElMaestro 2011-06-17 13:09
- Redosing study… luvblooms 2011-06-18 11:47
- Redosing study… GSTATS 2011-06-17 16:57
- Redosing study… luvblooms 2011-06-18 11:53
- Redosing study…ElMaestro 2011-06-17 13:09
- Redosing study… luvblooms 2011-06-17 12:50
- Redosing study… ElMaestro 2011-06-17 09:16
- Redosing study… Dr_Dan 2011-06-16 12:37
- Redosing study… swapnil.kuche 2011-06-16 08:35
Ing. Helmut Schütz