Bioequivalence and Bioavailability Forum

Missing samples in terminal elimination phase [Study As­sess­ment]

posted by Helmut  – Vienna, Austria, 2009-10-12 17:18 (6099 d 18:33 ago) – Posting: # 4341
Views: 8,407

Dear Bhupesh

agreeing with Jaime's post one more caveat: depending on the software you use, it may be dangerous to keep these values only as 'Missing'. For instance WinNonlin always interpolates linear - leading to a positive bias of the calculated AUC. See this post and this one as well. There's a tricky (and undocumented) workaround to get a correct estimate (essentially adding two partial areas), but this is nothing for beginners.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна! 
Helmut Schütz


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Complete thread:

• Missing samples in terminal elimination phase Bhupesh 2009-10-12 14:14 
  • Missing samples in terminal elimination phase Jaime_R 2009-10-12 14:51
    • Missing samples in terminal elimination phase yjlee168 2009-10-12 22:53
      • Missing samples in terminal elimination phase Jaime_R 2009-10-13 18:24
  • Missing samples in terminal elimination phaseHelmut 2009-10-12 15:18