Bioequivalence and Bioavailability Forum

BE parallel design [Study Assessment]

posted by Sathya – India, 2008-09-08 11:12 (6496 d 14:50 ago) – Posting: # 2335
Views: 9,851
(edited on 2008-09-08 11:46)

Dear ohlbe,

Thank you for your response.

I got sample SAS report of Cross over study. I tried the same dataset. I got all the values exactly except power. I tried different Calculation and formula. But unable to get the exact answer. Please help.

Here i attached required result and also my power calculations.

Power Calculations Using Different Formulae:-

Required Output:

Parameter Lcmax

lsmref    361.94

lsmtest   346.85

DF        22

mse       0.021091

se        0.041924

diff      -15.095

ratio     95.8295

intra_cv  14.5997

power     99.8158

lower     89.1733

upper     102.983

smanp1    0.000143

smanp2    1.113E-06

Method:

data Power2;

Estimate = -0.04260;

StdErr  = 0.04192;

DF = 22;

delta=log(1.25);

test1=(estimate+delta)/stderr;

test2=(estimate-delta)/stderr;

probt1=PROBT(test1,df,0);

probt2=PROBT(test2,df,0);

p1=1-probt1;

p2=probt2;

ANSWER =probt1 - probt2;

Power = answer*100;

run;

output

Obs  Estimate  StdErr   DF  delta    test1    test2     probt1   probt2

1    0.0426    0.04192  22  0.22314  6.33930  -4.30686  1.00000  .000142565

p1          p2          ANSWER  Power

.000001112  .000142565  0.99986 99.9856

—
Sathya

Complete thread:

BE parallel design Sathya 2008-09-06 06:46
- BE parallel design Ohlbe 2008-09-06 16:48
  - BE parallel design Sathya 2008-09-08 03:24
  - BE parallel designSathya 2008-09-08 09:12
    - a posteriori power... Jaime_R 2008-09-08 10:46
      - a posteriori power... Sathya 2008-09-08 11:51
        
        a posteriori power... Ohlbe 2008-09-08 12:27
        
        a posteriori power... Sathya 2008-09-10 09:49

BE parallel design [Study As­sess­ment]

Complete thread:

BE parallel design [Study Assessment]