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RegisterInfluence of sampling points on CV intra [Study Assessment]
Dear all,
One of my colleagues recently have performed a pilot study with alendronate (N=12), measuring alendronate in plasma, and results showed a CV intra of >50% for both Cmax and AUC, while CV intra described in literature is not so high (around 36-38%).
When reviewing the design of that study I found that sampling points were not as frequent as they should be (they were +0.50 h, +1.00 h, +1.50 h, +2.00 h,...) but I found more appropiate a frequency of 0.25h during the first 2 h in order to charactherize Cmax properly.
Do you think poor frequency of blood sampling could have influenced CV intra?
Thanks,
Edit: Category changed. [Helmut]
One of my colleagues recently have performed a pilot study with alendronate (N=12), measuring alendronate in plasma, and results showed a CV intra of >50% for both Cmax and AUC, while CV intra described in literature is not so high (around 36-38%).
When reviewing the design of that study I found that sampling points were not as frequent as they should be (they were +0.50 h, +1.00 h, +1.50 h, +2.00 h,...) but I found more appropiate a frequency of 0.25h during the first 2 h in order to charactherize Cmax properly.
Do you think poor frequency of blood sampling could have influenced CV intra?
Thanks,
Edit: Category changed. [Helmut]
Complete thread:
- Influence of sampling points on CV intraAverroes 2014-03-31 17:48
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Influence of sampling points on CV intra Helmut 2014-04-01 00:54
- Influence of sampling points on CV intra Averroes 2014-04-03 01:09
- Influence of sampling points on CV intra Helmut 2014-04-01 00:54
Ing. Helmut Schütz