Bioequivalence and Bioavailability Forum

Hi John!

❝ RASBE (Within sub SD of R > 0.294)

PHX6.3

Note that from ilat you not only get the PE but also the 90% CI:
102.11–119.55
from s²_WR → CV_WR 39.24%

❝ ABE

❝ T/R Ratio%    90% CI        Intra-sub CV%

❝ 110.15      101.84-119.14     28.08%

PE and CI.
I get a s²_WR of 0.139466 (PHX’ terminology: Var(Period*Formulation*Subject)_21) → CV_WR 38.69%
Have a look at s²_WT. Do you believe in this value? I don’t. Stupid design.

❝ I also (back) computed the intra-subject CV ABE's 90% CI using PowerTost

100*CVfromCI(lower=1.0184, upper=1.1914, n=52, design="2x3x3", robust=TRUE)
28.08115
100*CVfromCI(lower=1.0211, upper=1.1955, n=52, design="2x3x3")
28.51869

❝ Anyone smells something fishy here?

Strange. From the ABE model I get a CV_WR which is pretty close to the one from RSABE. I think we have to wait for Detlew returning from his vacation in three weeks.

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BTW, update PowerTOST to the latest version 1.1-03 (published 2013-05-03). See the NEWS.