Bioequivalence and Bioavailability Forum

Hi all,

Question... If I have a subject with only 2 out of 22 quantifiable plasma concentration(total 22 timepoints) while the rest are BLQs, is there any justification to drop him out of the analysis or run two sets of analysis (1 with all subjects, 1 without this subject)? His two quantifiable timepoints are adjacent to each other (lets say 1 and 1.5). He did take the medication.

All others subjects have quantifiable concentrations at most if not all timepoints. Concentration values show high degree of variability among subjects.

Thanks
John

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Edit: Category changed. [Helmut]