Bioequivalence and Bioavailability Forum • Cmin - search, search, search and once more: search

Cmin - search, search, search and once more: search [NCA / SHAM]

posted by d_labes – Berlin, Germany, 2012-07-31 15:33 (4659 d 20:46 ago) – Posting: # 9003
Views: 7,080

Dear RVR, dear VG,

❝ Cmin can be calculated manually from the obtained Bio-anlaytical concentration data - The first measured concentration of drug after the drug administration is the Cmin concentration for first dose and last measured concentration of the first dose will be the Cmin for the second dose of drug and the last measured concentration of the second dose will be the Cmin for the third dose … (steady state).

❝

❝ Formulae for calculating Cmin = Accum x Intercept x (e-lzT - e-kaT)

Seems a little bit strange for me :no:

.

We had a lot of discussions here in the forum regarding the metric Cmin. There you will find some more reliable definitions how to get Cmin in steady state.
Please do us the favour and search the Forum first before asking.

For an appetizer see this thread.

—
Regards,

Detlew

Complete thread:

Cmin calculation steady state VG 2012-07-30 07:02
- Cmin calculation steady state RVR 2012-07-30 11:51
  - Cmin calculation steady state VG 2012-07-31 11:14
  - Cmin - search, search, search and once more: searchd_labes 2012-07-31 13:33