Bioequivalence and Bioavailability Forum • Eyeball-PK

Eyeball-PK [NCA / SHAM]

posted by hiren379 – India, 2012-07-11 18:24 (4679 d 14:17 ago) – Posting: # 8935
Views: 24,223

Dear HS!

❝ The fact that your drug is completely in solution doesn’t prevent precipitation in the body. Blood ≠ Ringer’s solution.

Ya thanks for drawing my attention to mighty pH difference between nature's creation and Man's effort to become God.

❝ Apart from a small increase after end of infusion due to analytical variability sometimes you see an increase which may last for more than an hour – that’s an indication of precipitation.

Thanks for sharing your experience.

❝ You have to inspect the individual profiles and should not assume “this is an infusion, therefore C_max/t_max = end of infusion”.

❝ Still you have to check #1. So my answer is only a “conditional yes”. ;-)

Ok HS, now if you are accepting that elimination phase prevails (ok conditionally) after completion of infusion, the thing now acts like an IV bolus. So do you accept that in this hypothetical situation one must include maximum number of points for kel estimation as per your say on IV?

❝ Well – at least for i.v. as many as possible since analytical error is inverse proportional to concentration.

Complete thread:

Methods for calculation of half lives d_labes 2008-02-01 14:58
- Methods for calculation of half lives Helmut 2008-02-01 16:59
  - Methods for calculation of half lives Ohlbe 2008-02-02 23:00
    - Minimum AIC?! Helmut 2008-02-03 13:49
      - G (Kinetica) = R²adj (WinNonlin) Helmut 2008-02-04 01:12
  - Methods for calculation of half lives d_labes 2008-02-04 16:43
    - MAIC and beyond... Helmut 2008-02-04 17:49
- TTT method Helmut 2008-05-10 13:56
  - TTT method d_labes 2008-05-16 09:12
    - TTT method Helmut 2008-05-16 17:21
      - TTT method d_labes 2008-05-23 15:43
        
        TTT method hiren379 2012-07-11 11:11
        
        TTT method Ohlbe 2012-07-11 11:37
        
        TTT method hiren379 2012-07-11 11:44
        
        TTT method Ohlbe 2012-07-11 12:16
        
        TTT method hiren379 2012-07-11 12:53
        
        Eyeball-PK Helmut 2012-07-11 14:37
        
        Eyeball-PK hiren379 2012-07-11 15:28
        
        Eyeball-PK Helmut 2012-07-11 15:47
        
        Eyeball-PKhiren379 2012-07-11 16:24