Bioequivalence and Bioavailability Forum

AAC [NCA / SHAM]

posted by d_labes  – Berlin, Germany, 2012-05-23 18:55 (4728 d 22:26 ago) – Posting: # 8614
Views: 7,675

Dear Sandy!

❝ I am attached one image of Plot. In that plot, i want to calculate the mark area of plot.

❝ Kindly provide solution.

1. Calculate the area under the curve (AUC) as usual using the trapezoidal rule or whatever other method you prefer.
   
2. Calculate the area (also a trapezoid!) between the x-axis and the points x=0, Y(x=0) and x=9, Y(x=9).
   Lets call it Area9.
   
3. Subtract Area9 - AUC and voilà you have your 'AAC' .

Can you please enlighten us why your are interested in this rather uncommon metric? What's the meaning of your axes?

Complete thread:

• Area outside curve sandipmumbai 2012-05-22 15:00 
  • Area outside curve jag009 2012-05-22 15:40
  • Area outside curve ElMaestro 2012-05-22 15:43
  • AAC Helmut 2012-05-22 23:34
    • AAC sandipmumbai 2012-05-23 06:40
      • AAC jag009 2012-05-23 16:13
      • AACd_labes 2012-05-23 16:55
        • AUEC (Phoenix/WinNonlin Model 220) Helmut 2012-05-23 22:32
          • AUEC (Phoenix/WinNonlin Model 220) SDavis 2012-06-28 22:01
            • AUEC (Phoenix/WinNonlin Model 220) Helmut 2012-06-29 01:29