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RegisterCi > Ci-1 (excluding data points) [NCA / SHAM]
Hi Helmut,
Actually that particular CRO (maybe there are others) kept the subject's Cmax, Tmax and AUCt but assigned AUCinf, kel and t1/2 as undefined or "N.C."
One more question, what if the last two points of the elimination phase is going in the positive direction and the points before them (lets say 3 points, yes after Cmax) are declining?
❝ ❝ Should Kel be labelled as "Undefined"? Some CROs would say "Undefined" …
❝
❝ That would mean excluding the subject’s AUCs (AUCt unreliable, AUC∞ undefined). At least you could keep the subject’s Cmax in the data set (which is more variable).
Actually that particular CRO (maybe there are others) kept the subject's Cmax, Tmax and AUCt but assigned AUCinf, kel and t1/2 as undefined or "N.C."
One more question, what if the last two points of the elimination phase is going in the positive direction and the points before them (lets say 3 points, yes after Cmax) are declining?
Complete thread:
- Determining Elimination Constant (Kel) jag009 2012-03-15 19:05
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Ci > Ci-1 (excluding data points) Helmut 2012-03-16 01:46
- Ci > Ci-1 (excluding data points)jag009 2012-03-26 15:24
- Unreliable AUCt Helmut 2012-03-28 14:30
- Ci > Ci-1 (excluding data points) ElMaestro 2012-03-29 18:57
- Ci > Ci-1 (excluding data points)jag009 2012-03-26 15:24
- Ci > Ci-1 (excluding data points) Helmut 2012-03-16 01:46
Ing. Helmut Schütz