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RegisterCalculation of AUC0-72 [NCA / SHAM]
Dear Helmut,
"Late is not too late".
I am with you if the values in the last part of the concentration time course are <LOQ. But I think it's different with missing values (vial broken or so) especially in case of long half life drugs.
Because time points are spread occasionally with 24h in the last part, there may be a considerable portion of AUC missing.
Is this sentence then furthermore your opinion?
❝ sorry for the late response – I was driven by discussions about the drafted European BE-Guideline. 
"Late is not too late".
I am with you if the values in the last part of the concentration time course are <LOQ. But I think it's different with missing values (vial broken or so) especially in case of long half life drugs.
Because time points are spread occasionally with 24h in the last part, there may be a considerable portion of AUC missing.
❝ I wouldn’t start trying to get an estimate of C72.
Is this sentence then furthermore your opinion?
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
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![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
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- Calculation of AUC0-72 Jaime_R 2008-06-10 18:45
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- Regulators truncated Helmut 2009-06-19 22:35
- Regulators truncated ElMaestro 2009-06-19 22:16
- Regulators truncated Helmut 2009-06-18 15:44
- Regulators truncated d_labes 2009-06-18 15:26
- Luke 23:34 ElMaestro 2009-06-18 14:50
- Regulators truncated d_labes 2009-06-18 09:26
- Calculation of AUC0-72 d_labes 2008-09-05 15:00
- Calculation of AUC0-72 Helmut 2009-01-26 16:24
- Calculation of AUC0-72d_labes 2009-01-26 16:57
- Calculation of AUC0-72 Helmut 2009-01-26 17:20
- The missing 72h d_labes 2009-01-27 11:48
- The missing 72h Ohlbe 2009-01-28 00:00
- sensitivity analyses ? martin 2009-01-28 08:26
- Regulators ways are inscrutable d_labes 2009-01-28 09:54
- Regulators ways are inscrutable (at least the French) Ohlbe 2009-01-28 10:16
- The missing 72h ElMaestro 2009-01-28 14:32
- Page 3848 of 221 d_labes 2009-01-28 14:51
- Partial AUC calculation Astea 2017-03-11 20:14
- Partial AUC calculation mittyri 2017-03-16 19:46
- The missing 72h Ohlbe 2009-01-28 00:00
- The missing 72h d_labes 2009-01-27 11:48
- Calculation of AUC0-72 Helmut 2009-01-26 17:20
- Calculation of AUC0-72d_labes 2009-01-26 16:57
- Calculation of AUC0-72 Helmut 2009-01-26 16:24
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- Calculation of AUC0-72 Jaime_R 2008-06-10 12:18
Ing. Helmut Schütz