old study re analysis [NCA / SHAM]

posted by d_labes  – Berlin, Germany, 2008-08-08 10:42 (6113 d 14:56 ago) – Posting: # 2163
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Dear MiLi,

❝ [...] I made the program myself with sas, maybe there are some errors in it but [...]



Have a look at

Arturo Soto Matos-Pita, Bernardo de Miguel Lillo
Noncompartmental Pharmacokinetics and Bioequivalence Analysis
www.lexjansen.com/pharmasug/2005/statisticspharmacokinetics/sp07.pdf

May be this helps to validate your own SAS program.
But note the bioequivalence test (90% confidence interval) in this paper is not correct. 1.761 in the macro anova has to be replaced by the appropriate t-value.
The sequence test is also not correct implemented.

Regarding your task "re-analysis" I subscribe to the view of HS

❝ Sincere condolences. :crying:

Dress warmly and prepare yourself to have trouble over and over in such tasks.

Regards,

Detlew

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