Bioequivalence and Bioavailability Forum

Dear MiLi!

❝ I made the program myself with sas, maybe there are some errors in it but the results about elimination rate fit with the graphs.

OK, if there are increasing values you may fit them, but without physiological meaning (assuming your formulation is not a transdermal patch, an i.m. suspension, etc.).
Since in a linear PK model the slowest phase 'drives' the profile you would see the absorption in the later part of the profile and elimination in the former. That's the classical 'flip-flop' situation. How do your 'half lives' compare to reported ones from the literature?

❝ The data are really strange!!!

Again; what's the 'half life'? If values are close to the LLOQ of the method and there's a lot of variability (old study = old method) it may also be possible that this increase is due to pure chance (with just 7 sampling points overall I would expect that quite often you had just 3 points available for estimating k_el).

❝ ❝ There's an American phrase for it: 'Lights on, nobody at home.'

❝

❝ I think I see the idea but what does that precisely mean?! Thanks to increase my culture!

It describes a person who only seems to be present, but actually is absent-minded, or even worse has no mind at all.
I was referring to these guys running the first analysis without even noticing problems.