Bioequivalence and Bioavailability Forum

Thanks for your answer.

❝ Sincere condolences.

❝ Interesting. I hope the protocol did state one metric as the main parameter - otherwise you will run into multiplicity issues.

❝ I guess you mean ⅓ of C_max?

Yes, sorry

❝ Do I get you right: you 'see' increasing values in ¹/₆ of subjects?

Yes!!!

❝ What program are you using? K_el by definition is positive (denoting a transfer from the central compartment); all programs specialized in NCA PK analysis would come up with an error message.

I made the program myself with sas, maybe there are some errors in it but the results about elimination rate fit with the graphs. The data are really strange!!!

❝ There's an American phrase for it: 'Lights on, nobody at home.'

I think I see the idea but what does that precisely mean?! Thanks to increase my culture!

❝ Forget it (sorry).

that's what i was afraid of. Thanks a lot