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Registerold study re analysis [NCA / SHAM]
Hello,
I am working on a old bioavailability study.
there is only 7 sample times. The first analysis has been done with incremental troncated AUC.
I have calculated AUCinf but the problem is that 1/3 of Tmax is at the last or the last but one sample time. The data even give some (1/6!!) negative Ke!!! It is not a problem in my program because you can verify it on graph.
My question is : According to the study report, there has been no problem to perform the analysis on this data. But, I wonder about the (poor ?) credit that we can give to the results of this first analysis.
Sorry for my poor english.
--
Edit: Category changed. [Jaime]
I am working on a old bioavailability study.
there is only 7 sample times. The first analysis has been done with incremental troncated AUC.
I have calculated AUCinf but the problem is that 1/3 of Tmax is at the last or the last but one sample time. The data even give some (1/6!!) negative Ke!!! It is not a problem in my program because you can verify it on graph.
My question is : According to the study report, there has been no problem to perform the analysis on this data. But, I wonder about the (poor ?) credit that we can give to the results of this first analysis.
Sorry for my poor english.
--
Edit: Category changed. [Jaime]
Complete thread:
- old study re analysisMiLi 2008-08-06 10:56
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- old study re analysis Helmut 2008-08-07 16:00
- old study re analysis MiLi 2008-08-07 17:28
- old study re analysis Helmut 2008-08-07 17:54
- old study re analysis d_labes 2008-08-08 08:42
- old study re analysis MiLi 2008-08-07 17:28
- old study re analysis Helmut 2008-08-07 16:00
Ing. Helmut Schütz