G (Kinetica) = R²adj (WinNonlin) [NCA / SHAM]
Dear Ohlbe!
OK, I ran the example in Kinetica; the parameter ‘G’ in the output is numerically identical to R2adj.
Just another quote supporting “eye-ball PK”:*
❝ … strange enough there’s a parameter ‘G’ in the output, which is neither described in the online-help nor the manual (v4.1.1, 2007).
❝ I will try to find out the next days, what this parameter might be…
OK, I ran the example in Kinetica; the parameter ‘G’ in the output is numerically identical to R2adj.
Just another quote supporting “eye-ball PK”:*
‘The selection of the most suitable time interval cannot be left to a programmed algorithm based on mathematical criteria, but necessitates scientific judgment by both the clinical pharmacokineticist and the person who determinend the concentrations and knows about their reliability.’
- D Hauschke, VW Steinijans and I Pigeot
Bioequivalence Studies in Drug Development: Methods and Applications
Wiley, New York, pp 20-23 (2007)
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Complete thread:
- Methods for calculation of half lives d_labes 2008-02-01 14:58
- Methods for calculation of half lives Helmut 2008-02-01 16:59
- Methods for calculation of half lives Ohlbe 2008-02-02 23:00
- Minimum AIC?! Helmut 2008-02-03 13:49
- G (Kinetica) = R²adj (WinNonlin)Helmut 2008-02-04 01:12
- Minimum AIC?! Helmut 2008-02-03 13:49
- Methods for calculation of half lives d_labes 2008-02-04 16:43
- MAIC and beyond... Helmut 2008-02-04 17:49
- Methods for calculation of half lives Ohlbe 2008-02-02 23:00
- TTT method Helmut 2008-05-10 13:56
- TTT method d_labes 2008-05-16 09:12
- TTT method Helmut 2008-05-16 17:21
- TTT method d_labes 2008-05-23 15:43
- TTT method hiren379 2012-07-11 11:11
- TTT method Ohlbe 2012-07-11 11:37
- TTT method hiren379 2012-07-11 11:44
- TTT method Ohlbe 2012-07-11 12:16
- TTT method hiren379 2012-07-11 12:53
- Eyeball-PK Helmut 2012-07-11 14:37
- Eyeball-PK hiren379 2012-07-11 15:28
- Eyeball-PK Helmut 2012-07-11 15:47
- Eyeball-PK hiren379 2012-07-11 16:24
- Eyeball-PK Helmut 2012-07-11 15:47
- Eyeball-PK hiren379 2012-07-11 15:28
- Eyeball-PK Helmut 2012-07-11 14:37
- TTT method hiren379 2012-07-11 12:53
- TTT method Ohlbe 2012-07-11 12:16
- TTT method hiren379 2012-07-11 11:44
- TTT method Ohlbe 2012-07-11 11:37
- TTT method hiren379 2012-07-11 11:11
- TTT method d_labes 2008-05-23 15:43
- TTT method Helmut 2008-05-16 17:21
- TTT method d_labes 2008-05-16 09:12
- Methods for calculation of half lives Helmut 2008-02-01 16:59