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RegisterMethods for calculation of half lives [NCA / SHAM]
Dear All,
i would like to hear your opinion about the calculation of terminal half life, especially of choosing the linear part.
Is it done by you via 'informed' look at the concentration time curve (half logarithmic of course) or do you use any automatic method?
As i know, WINNONLIN has built in a method using the adjusted R2.
How are your experiences with that?
Does it lead to reasonable choices?
Are there any other methods (automatic or half automatic) used?
I think in view of the standardization of the pharmacokinetic evaluation within the framework of bioequivalence studies an automated method would be desirable.
This would remove the subjectivity in estimating the AUC values, especially the extrapolated part, if possible.
i would like to hear your opinion about the calculation of terminal half life, especially of choosing the linear part.
Is it done by you via 'informed' look at the concentration time curve (half logarithmic of course) or do you use any automatic method?
As i know, WINNONLIN has built in a method using the adjusted R2.
How are your experiences with that?
Does it lead to reasonable choices?
Are there any other methods (automatic or half automatic) used?
I think in view of the standardization of the pharmacokinetic evaluation within the framework of bioequivalence studies an automated method would be desirable.
This would remove the subjectivity in estimating the AUC values, especially the extrapolated part, if possible.
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Methods for calculation of half livesd_labes 2008-02-01 14:58
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Methods for calculation of half lives Helmut 2008-02-01 16:59
- Methods for calculation of half lives Ohlbe 2008-02-02 23:00
- Minimum AIC?! Helmut 2008-02-03 13:49
- G (Kinetica) = R²adj (WinNonlin) Helmut 2008-02-04 01:12
- Minimum AIC?! Helmut 2008-02-03 13:49
- Methods for calculation of half lives d_labes 2008-02-04 16:43
- MAIC and beyond... Helmut 2008-02-04 17:49
- Methods for calculation of half lives Ohlbe 2008-02-02 23:00
- TTT method Helmut 2008-05-10 13:56
- TTT method d_labes 2008-05-16 09:12
- TTT method Helmut 2008-05-16 17:21
- TTT method d_labes 2008-05-23 15:43
- TTT method hiren379 2012-07-11 11:11
- TTT method Ohlbe 2012-07-11 11:37
- TTT method hiren379 2012-07-11 11:44
- TTT method Ohlbe 2012-07-11 12:16
- TTT method hiren379 2012-07-11 12:53
- Eyeball-PK Helmut 2012-07-11 14:37
- Eyeball-PK hiren379 2012-07-11 15:28
- Eyeball-PK Helmut 2012-07-11 15:47
- Eyeball-PK hiren379 2012-07-11 16:24
- Eyeball-PK Helmut 2012-07-11 15:47
- Eyeball-PK hiren379 2012-07-11 15:28
- Eyeball-PK Helmut 2012-07-11 14:37
- TTT method hiren379 2012-07-11 12:53
- TTT method Ohlbe 2012-07-11 12:16
- TTT method hiren379 2012-07-11 11:44
- TTT method Ohlbe 2012-07-11 11:37
- TTT method hiren379 2012-07-11 11:11
- TTT method d_labes 2008-05-23 15:43
- TTT method Helmut 2008-05-16 17:21
- TTT method d_labes 2008-05-16 09:12
- Methods for calculation of half lives Helmut 2008-02-01 16:59
Ing. Helmut Schütz