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RegisterRegarding the Cτ,ss (Ctau at steady state) calculation [NCA / SHAM]
Dear All,
I have calculated Cτ,ss for a steady state study using the formula
Clast*exp(-Kel(τ-tlast)) for the concentration data on day6. The dosing interval for the study was 12 hrs and the sampling schedule on day6 is also having 12.00 hr and extended upto 36.00 hrs. I have refered the forum and the lectures given on these topics but i am not able to get conclusion on which data i have to perform BE for Cτ,ss
MurthyNaidu
Edit: Category changed. [Helmut]
I have calculated Cτ,ss for a steady state study using the formula
Clast*exp(-Kel(τ-tlast)) for the concentration data on day6. The dosing interval for the study was 12 hrs and the sampling schedule on day6 is also having 12.00 hr and extended upto 36.00 hrs. I have refered the forum and the lectures given on these topics but i am not able to get conclusion on which data i have to perform BE for Cτ,ss
- For the data calculated using the formula
- For The data at 12.00 hr on day6
- For The average of all predose samples collected
- For the Pre dose sample data collected on Day 6
MurthyNaidu
Edit: Category changed. [Helmut]
Complete thread:
- Regarding the Cτ,ss (Ctau at steady state) calculationmurthynaidu 2014-06-20 14:46
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- What’s stated in the protocol? Helmut 2014-06-20 15:20
- What’s stated in the protocol? murthynaidu 2014-06-20 15:48
- Avoid ambiguities… Helmut 2014-06-20 16:17
- What’s stated in the protocol? murthynaidu 2014-06-20 15:48
- What’s stated in the protocol? Helmut 2014-06-20 15:20
Ing. Helmut Schütz