Bioequivalence and Bioavailability Forum • Errors happen

Errors happen [NCA / SHAM]

posted by fno – Belgium, 2014-03-20 12:03 (4062 d 21:33 ago) – Posting: # 12676
Views: 20,997

❝ Me too :cool: !

❝ You are absolutely correct in questioning these formulas. What here would be correct is:

❝ 24*(-0.20027)+4.60838 = -0.1981

❝ and

❝ 16.92*(-0.19992)+4.55224=1.169594

And then (from Jungmin's AUCt),

For ref:
Clast_pred=exp(-0.1981)=0.82029
AUCinf_pred=401.88595+0.82029/0.20027=405.98186

For test:
Clast_pred=exp(1.169594)=3.22068
AUCinf_pred=367.642+3.22068/0.19992=383.75186

T/R=94.5244%
Bias=-0.5006%

—
Kind regards,
Fabrice

Complete thread:

Calculation of AUCt yckim 2007-11-27 02:46
- Calculation of AUCt, AUCall, AUCinf... Helmut 2007-11-27 22:02
  - Calculation of AUCt, AUCall, AUCinf... yckim 2007-11-28 02:44
    - Calculation of AUCt, AUCall, AUCinf... Helmut 2007-11-28 03:49
      - Calculation of AUCt, AUCall, AUCinf... jmlee 2008-10-10 08:29
        
        Calculation of AUCt, AUCall, AUCinf... Helmut 2008-10-10 17:48
        Calculation of AUCt, AUCall, AUCinf... mittyri 2014-03-19 19:15
        
        Errors happen d_labes 2014-03-20 08:26
        
        Errors happenfno 2014-03-20 11:03
  - Calculation of AUCt, AUCall, AUCinf... Ohlbe 2007-11-28 10:37
    - Calculation of AUCt, AUCall, AUCinf... Helmut 2007-11-28 12:28
      - References Helmut 2007-11-28 17:58