Bioequivalence and Bioavailability Forum • Yep. Almost there.

Yep. Almost there. [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2013-01-16 00:30 (4911 d 21:46 ago) – Posting: # 9857
Views: 18,049

Hi John,

❝ […] How do you come up with the CL value?

By ignoring the √… Unbelievable, since printed in such a large font.

❝ According to the equation in the warfarin guidance

❝ (1-alpha)100%CI = (SWT/SWR)/Sqrt(F₁), (SWT/SWR)/Sqrt(F₂),

❝ where F₁=F_{alpha/2,v1,v2}, F₂=F_{1-alpha/2,v1,v2}

❝

❝ I ended up getting 0.13134956, 0.306502082???

Duno. My steps:


 s²_WT        s²_WR

0.0031048  0.015474

 s_WT         s_WR      s_WT/s_WR

0.055721   0.12440   0.44794

α 0.1, therefore,


 F_0.05,16,16   F_0.95,16,16

2.3335       0.42854

√F_0.05,16,16  √F_0.95,16,16

1.5278       0.65463

CL_lo      CL_hi

0.29324   0.68427

❝ I am not smoking weed at this moment, its illegal anyway...

Well,

:smoke:

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Science Quotes

Complete thread:

FDA’s aggregate BE for NTIDs: example Helmut 2013-01-13 15:54
- 404 d_labes 2013-01-13 19:06
  - URL corrected Helmut 2013-01-13 20:49
    - URL corrected jag009 2013-01-14 21:09
      - THX! Helmut 2013-01-14 21:50
        
        THX! jag009 2013-01-14 21:53
        
        Home stretch Helmut 2013-01-14 22:07
        
        Home stretch jag009 2013-01-14 22:24
        
        estimate K2K 2013-01-16 04:48
        
        only a typo in John’s code Helmut 2013-01-16 14:00
        
        only a typo in John’s code K2K 2013-01-17 04:46
- FDA’s aggregate BE for NTIDs: example jag009 2013-01-14 23:04
  - Variances from ABE: different model Helmut 2013-01-15 15:41
    - Variances from ABE: different model jag009 2013-01-15 17:58
      - Variances from ABE: different model Helmut 2013-01-15 18:09
        
        Variances from ABE: different model jag009 2013-01-15 18:17
        
        Yep. Almost there.Helmut 2013-01-15 23:30
        
        Yep. Almost there. jag009 2013-01-16 16:14
        
        Done Helmut 2013-01-20 12:58
        
        Variances from ABE: different model jag009 2013-01-15 18:19
        
        Variances from ABE: different model Helmut 2013-01-15 18:29
        
        Variances from ABE: different model jag009 2013-01-15 19:49
        Variances from ABE: different model jag009 2013-01-16 19:35
        
        Variances from ABE: different model Helmut 2013-01-16 19:39

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