Bioequivalence and Bioavailability Forum • Ratio 125%: reformulate

Ratio 125%: reformulate [RSABE / ABEL]

posted by Ohlbe – France, 2012-05-09 18:40 (4753 d 20:36 ago) – Posting: # 8547
Views: 7,712

Dear drsinghs,

❝ Ok if my study is for EMA and observed ratio for AUCt is 125% with 90% CI 110 lower and 140 upper, Can I expect 90% CI to be within 80.00-125.00% in replicate design study.

If your observed T/R ratio is 125 %, your chances to get a 90 % CI within 80.00 - 125.00 % in the next study, even with a replicate design, are close to nil.

Regards
Ohlbe

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Regards
Ohlbe

Complete thread:

Full replicate design PTM139 2012-05-03 06:01
- Full replicate design Dr_Dan 2012-05-03 15:14
  - Full replicate design PTM139 2012-05-03 16:35
    - HVDs/HVDPs: tricky business! Helmut 2012-05-03 16:58
      - HVDs/HVDPs: tricky business! PTM139 2012-05-05 07:16
      - HVDs/HVDPs: tricky business! drsinghs 2012-05-09 12:33
        
        Ratio 125% Helmut 2012-05-09 13:05
        
        Ratio 125% drsinghs 2012-05-09 13:41
        
        Ratio 125%: reformulateOhlbe 2012-05-09 16:40
        
        Ratio 125%: reformulate drsinghs 2012-05-10 05:49
        
        HVDs/HVDPs: tricky business! ElMaestro 2012-05-09 15:00
        
        HVDs/HVDPs: tricky business! drsinghs 2012-05-10 05:43