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Registerlog(e) vs. log(10) [RSABE / ABEL]
posted by Helmut 
– Vienna, Austria, 2010-11-09 22:31 (5301 d 11:45 ago) – Posting: # 6129
Views: 14,102
Hi Angus!
Yes, I saw your post already. I guessed that also, but concentrated on CV vs. sigma – which may make one’s life miserable. In PK (with a few exceptions) ln is used, because it comes handy dealing with the calculus. It’s much easier with base e than with base 10. Of course any base can be used, even the logarithmus dualis (ld – base 2); not uncommon in the IT world. As long as you are consistent, everything is fine.
Some anecdotes: I once saw an application for Australia, where log10 was used. So far, so good. But next they fiddled around with a posteriori power (sigh!). In calculating the CVintra they used the common formula, ignoring that their MSE was in log10 rather than loge scale and got stuck. Gotcha! I also saw an enquiry from the Malaysian authority, asking whether log10 or loge was used in the analysis. Obviously they had a good reason to ask.
Yes, I saw your post already. I guessed that also, but concentrated on CV vs. sigma – which may make one’s life miserable. In PK (with a few exceptions) ln is used, because it comes handy dealing with the calculus. It’s much easier with base e than with base 10. Of course any base can be used, even the logarithmus dualis (ld – base 2); not uncommon in the IT world. As long as you are consistent, everything is fine.
Some anecdotes: I once saw an application for Australia, where log10 was used. So far, so good. But next they fiddled around with a posteriori power (sigh!). In calculating the CVintra they used the common formula, ignoring that their MSE was in log10 rather than loge scale and got stuck. Gotcha! I also saw an enquiry from the Malaysian authority, asking whether log10 or loge was used in the analysis. Obviously they had a good reason to ask.
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
Complete thread:
- reference scaled bioequivalence AngusMcLean 2010-11-07 14:55
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- reference scaled bioequivalence Helmut 2010-11-07 16:08
- reference scaled bioequivalence AngusMcLean 2010-11-08 22:22
- RSABE: FDA vs. EMA Helmut 2010-11-09 02:13
- Farside CV relabelling d_labes 2010-11-09 10:42
- Farside CV relabelling Helmut 2010-11-09 15:10
- Laszlo's constant d_labes 2010-11-09 16:46
- Farside CV relabelling AngusMcLean 2010-11-09 17:12
- Widened calculations step by step d_labes 2010-11-09 19:48
- Widened calculations step by step AngusMcLean 2010-11-09 20:46
- ln vs. log Helmut 2010-11-09 22:07
- ln on US calculators! d_labes 2010-11-10 08:31
- Spreadsheet addiction Helmut 2010-11-10 13:42
- Widened calculations step by step AngusMcLean 2010-11-09 20:46
- CV vs. sigma Helmut 2010-11-09 20:11
- CV vs. sigma AngusMcLean 2010-11-09 20:57
- log(e) vs. log(10)Helmut 2010-11-09 21:31
- slide 15 of the Pharsight presentation SDavis 2010-11-19 18:02
- CV vs. sigma AngusMcLean 2010-11-09 20:57
- Widened calculations step by step d_labes 2010-11-09 19:48
- Farside CV relabelling Helmut 2010-11-09 15:10
- one more ref. for the ref. list of RSABE yjlee168 2010-11-30 07:16
- Great! Helmut 2010-11-30 15:44
- Farside CV relabelling d_labes 2010-11-09 10:42
- RSABE: FDA vs. EMA Helmut 2010-11-09 02:13
- reference scaled bioequivalence AngusMcLean 2010-11-08 22:22
- reference scaled bioequivalence Helmut 2010-11-07 16:08
Ing. Helmut Schütz