Bioequivalence and Bioavailability Forum

Widened calculations step by step [RSABE / ABEL]

posted by d_labes  – Berlin, Germany, 2010-11-09 20:48 (5710 d 15:59 ago) – Posting: # 6124
Views: 17,346

Dear Angus,

❝ Please can you advise as to my error,

Lets try it step by step:

First evaluate log(1.25)/0.25 = 0.892574205....

Second: Convert the CV to the within-subject standard error for Reference:
  sigmaRef=sqrt(log((CV/100)2+1))
gives for CV=30%
  sigmaRef=0.293560379....

Third: Calculate
  exp(+0.892574205*sigmaRef
Should give you for the lower bound
  exp(-0.892574205*0.293560379)=0.769492231
and for the upper bound
  exp(+0.892574205*0.293560379)=1.29955828.

Fouth: Change the numbers to percent is left to you.

BTW: I think you could figure out this all by your self in a couple of minutes if you remember your high school math. Or didn't you sympathize with your math teacher?

Hope this helps.

Complete thread:

• reference scaled bioequivalence AngusMcLean 2010-11-07 14:55 
  • reference scaled bioequivalence Helmut 2010-11-07 16:08
    • reference scaled bioequivalence AngusMcLean 2010-11-08 22:22
      • RSABE: FDA vs. EMA Helmut 2010-11-09 02:13
        • Farside CV relabelling d_labes 2010-11-09 10:42
          • Farside CV relabelling Helmut 2010-11-09 15:10
            • Laszlo's constant d_labes 2010-11-09 16:46
          • Farside CV relabelling AngusMcLean 2010-11-09 17:12
            • Widened calculations step by stepd_labes 2010-11-09 19:48
              • Widened calculations step by step AngusMcLean 2010-11-09 20:46
                • ln vs. log Helmut 2010-11-09 22:07
                • ln on US calculators! d_labes 2010-11-10 08:31
                  • Spreadsheet addiction Helmut 2010-11-10 13:42
            • CV vs. sigma Helmut 2010-11-09 20:11
              • CV vs. sigma AngusMcLean 2010-11-09 20:57
                • log(e) vs. log(10) Helmut 2010-11-09 21:31
              • slide 15 of the Pharsight presentation SDavis 2010-11-19 18:02
        • one more ref. for the ref. list of RSABE yjlee168 2010-11-30 07:16
          • Great! Helmut 2010-11-30 15:44