Bioequivalence and Bioavailability Forum • Farside CV relabelling

Farside CV relabelling [RSABE / ABEL]

posted by AngusMcLean – USA, 2010-11-09 18:12 (5301 d 16:15 ago) – Posting: # 6123
Views: 13,830

The reason for the confusion is we do not know the calculation that is being made by Pharsight. Consequently we do not know conceptually it is incorrect or if there is an error in it.

I had difficulty getting the same number you got so I must not be interpreting your equation correctly.
exp(+log(1.25)*sigma_Ref/0.25)

For sigma = 0.30 I get 1.3221 for above calculation (when exp(+log(1.25) is used. Am I misunderstanding the parenthesis used? First I evaluated e^log1.25= 1.101761

That is (1.101761)*0.3/0.25 =1.3221

Please can you advise as to my error,

Angus

Edit: Full quote removed. Please delete anything from the text of the original poster which is not necessary in understanding your answer; see also this post! [Helmut]

Complete thread:

reference scaled bioequivalence AngusMcLean 2010-11-07 14:55
- reference scaled bioequivalence Helmut 2010-11-07 16:08
  - reference scaled bioequivalence AngusMcLean 2010-11-08 22:22
    - RSABE: FDA vs. EMA Helmut 2010-11-09 02:13
      - Farside CV relabelling d_labes 2010-11-09 10:42
        
        Farside CV relabelling Helmut 2010-11-09 15:10
        
        Laszlo's constant d_labes 2010-11-09 16:46
        
        Farside CV relabellingAngusMcLean 2010-11-09 17:12
        
        Widened calculations step by step d_labes 2010-11-09 19:48
        
        Widened calculations step by step AngusMcLean 2010-11-09 20:46
        
        ln vs. log Helmut 2010-11-09 22:07
        ln on US calculators! d_labes 2010-11-10 08:31
        
        Spreadsheet addiction Helmut 2010-11-10 13:42
        
        CV vs. sigma Helmut 2010-11-09 20:11
        
        CV vs. sigma AngusMcLean 2010-11-09 20:57
        
        log(e) vs. log(10) Helmut 2010-11-09 21:31
        
        slide 15 of the Pharsight presentation SDavis 2010-11-19 18:02
      - one more ref. for the ref. list of RSABE yjlee168 2010-11-30 07:16
        
        Great! Helmut 2010-11-30 15:44