Bioequivalence and Bioavailability Forum • Unknown x corrected?

Unknown x corrected? [RSABE / ABEL]

posted by d_labes – Berlin, Germany, 2010-10-01 14:14 (5751 d 12:40 ago) – Posting: # 5970
Views: 41,023

Dear J. Detlor,

❝ I saw this and thought I'd post my opinion.

❝

❝ I believe the calculated x value represents the 'true' value of squared difference ((Y_T-Y_R)²)). If we simply square the log difference, we actually have (Y_T-Y_R)²)) + sigma_d² (As shown here)

Thanks for your opinion.

But I'm not quite sure if this applies in our context.
What makes me curious about this is that in the various papers about scaled ABE and also about Individual BE (where (µ_T-µ_R)² is also part of the IBE criterion) there is not any hint of such a 'correction'.
:ponder:

—
Regards,

Detlew

Complete thread:

Reference scaled BE - FDA (and FARTSSIE update) ddubins 2010-04-26 20:28
- Reference scaled ABE - FDA d_labes 2010-04-27 08:58
  - Reference scaled ABE - FDA ElMaestro 2010-04-27 13:39
    - Factor 2 is unbiased d_labes 2010-04-27 14:30
    - Biased bonus from MoM d_labes 2010-05-04 12:10
      - Biased bonus from MoM ElMaestro 2010-05-04 12:54
        
        Mixed MoM d_labes 2010-05-04 14:40
        
        Mixed MoM ElMaestro 2010-05-04 15:08
        
        R and G, CSH and UN d_labes 2010-05-05 10:42
        
        A sailor gets confused ElMaestro 2010-05-05 11:49
        
        Confused V/Z matratzen and tips d_labes 2010-05-05 14:49
        
        superb post! ElMaestro 2010-05-05 21:32
        
        Gambling with UN d_labes 2010-05-06 11:00
        
        Mixed MoM yjlee168 2010-05-05 09:12
- Reference scaled BE - FDA (and FARTSSIE update) KR 2010-04-27 13:14
- Reference scaled BE - EMA Helmut 2010-04-27 14:58
  - Reference scaled BE - EMA ddubins 2010-04-27 17:52
    - Partial replicate design and FDA ABE code d_labes 2010-04-28 09:47
    - Reference scaled BE - EMA Helmut 2010-04-28 14:46
    - Switching - null sWR d_labes 2010-05-04 14:04
- The unknown x d_labes 2010-05-06 13:26
  - The unknown x jdetlor 2010-09-28 17:22
    - Unknown x corrected?d_labes 2010-10-01 12:14
      - Unknown x corrected? Qilex 2016-09-21 12:25
        
        Official unknown x d_labes 2016-09-21 13:22