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RegisterReference scaled ABE - FDA [RSABE / ABEL]
Hi Dave,
wow! Very valuable contribution!
Fascinating: The codes provided rely solely on suitably choosen intra-subject contrasts! Sometimes called Method of Moments if I'm not wrong. No explicit mixed effects modeling(!) with the exception of the "conventional" unscaled ABE analysis for a fully (4-period) replicate design.
BTW: What is missing is explicit code for ABE evaluation for the partial replicate design in case of sWR < 0.294 (CV = 30%): "The two one-sided test procedure must be used for PK parameters with sWR < 0.294."
BTW2: It is not clear why they recommend Proc MIXED in case of fully replicate design and Proc GLM in case of partial replicate. In both cases the call to these procedures have only sequence as fixed effect. They only serve as means to get the sequence "stratified" means of the corresponding inter-subject contrasts. Or is this meant with respect to the unscaled ABE evaluation?
wow! Very valuable contribution!
Fascinating: The codes provided rely solely on suitably choosen intra-subject contrasts! Sometimes called Method of Moments if I'm not wrong. No explicit mixed effects modeling(!) with the exception of the "conventional" unscaled ABE analysis for a fully (4-period) replicate design.
BTW: What is missing is explicit code for ABE evaluation for the partial replicate design in case of sWR < 0.294 (CV = 30%): "The two one-sided test procedure must be used for PK parameters with sWR < 0.294."
BTW2: It is not clear why they recommend Proc MIXED in case of fully replicate design and Proc GLM in case of partial replicate. In both cases the call to these procedures have only sequence as fixed effect. They only serve as means to get the sequence "stratified" means of the corresponding inter-subject contrasts. Or is this meant with respect to the unscaled ABE evaluation?
—
Regards,
Detlew
Regards,
Detlew
Complete thread:
- Reference scaled BE - FDA (and FARTSSIE update) ddubins 2010-04-26 20:28
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Reference scaled ABE - FDAd_labes 2010-04-27 08:58
- Reference scaled ABE - FDA ElMaestro 2010-04-27 13:39
- Factor 2 is unbiased d_labes 2010-04-27 14:30
- Biased bonus from MoM d_labes 2010-05-04 12:10
- Biased bonus from MoM ElMaestro 2010-05-04 12:54
- Mixed MoM d_labes 2010-05-04 14:40
- Mixed MoM ElMaestro 2010-05-04 15:08
- R and G, CSH and UN d_labes 2010-05-05 10:42
- A sailor gets confused ElMaestro 2010-05-05 11:49
- Confused V/Z matratzen and tips d_labes 2010-05-05 14:49
- superb post! ElMaestro 2010-05-05 21:32
- Gambling with UN d_labes 2010-05-06 11:00
- superb post! ElMaestro 2010-05-05 21:32
- Confused V/Z matratzen and tips d_labes 2010-05-05 14:49
- A sailor gets confused ElMaestro 2010-05-05 11:49
- R and G, CSH and UN d_labes 2010-05-05 10:42
- Mixed MoM yjlee168 2010-05-05 09:12
- Mixed MoM ElMaestro 2010-05-04 15:08
- Mixed MoM d_labes 2010-05-04 14:40
- Biased bonus from MoM ElMaestro 2010-05-04 12:54
- Reference scaled ABE - FDA ElMaestro 2010-04-27 13:39
- Reference scaled BE - FDA (and FARTSSIE update) KR 2010-04-27 13:14
- Reference scaled BE - EMA Helmut 2010-04-27 14:58
- Reference scaled BE - EMA ddubins 2010-04-27 17:52
- Partial replicate design and FDA ABE code d_labes 2010-04-28 09:47
- Reference scaled BE - EMA Helmut 2010-04-28 14:46
- Switching - null sWR d_labes 2010-05-04 14:04
- Reference scaled BE - EMA ddubins 2010-04-27 17:52
- The unknown x d_labes 2010-05-06 13:26
- The unknown x jdetlor 2010-09-28 17:22
- Unknown x corrected? d_labes 2010-10-01 12:14
- Unknown x corrected? Qilex 2016-09-21 12:25
- Official unknown x d_labes 2016-09-21 13:22
- Unknown x corrected? Qilex 2016-09-21 12:25
- Unknown x corrected? d_labes 2010-10-01 12:14
- The unknown x jdetlor 2010-09-28 17:22
- Reference scaled ABE - FDAd_labes 2010-04-27 08:58
Ing. Helmut Schütz