Nice looking three-headed hydra mutant [RSABE / ABEL]

posted by d_labes  – Berlin, Germany, 2010-04-01 17:20 (5935 d 01:20 ago) – Posting: # 4995
Views: 31,266

Ahoy Old Sailor,

❝ Section 6.2.3.1.2.5.7.2: Statistical handling of volunteers

❝ Each subject will be stratified into one of three sequences.


❝ Section 8.4.9.8.3.5.1.5: Statistics

❝ The full analysis set consists of the 14 volunteers that first complete sequence ABB, plus the 14 volunteers that first complete sequence BAB, plus plus the 14 volunteers that first complete sequence BBA.


:-D Nice idea, as always: ElMaestro to the rescue!

Meanwhile I have inspected the Extra-reference three-headed hydra, captured on my last journey on the Bear way using some Schützomycin for immobilizing (a paradox effect, which occurs only for hydras).

Whatever imbalance I put on it, the expected mean squares always show that the error term for the sequence effect is simply subject(sequence), as my bogus little RANDOM friend tells me.

BTW: Played with the data set
Le Roux et.al
"Use of repeated cross-over design in assessing bioequivalence: (within and between subjects variability - Schuirmann confidence intervals estimation)"
Eur. J. Drug Metab. Pharmacokin. 23(2), 339-345 (1998)

Have a nice Easter.

Regards,

Detlew

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