Bioequivalence and Bioavailability Forum • Estimated knowledge

Estimated knowledge [RSABE / ABEL]

posted by sdu – 2010-01-26 22:21 (5588 d 18:38 ago) – Posting: # 4649
Views: 15,025

Thank you for the nice summary of Toutfalusi et al.'s paper
I also read the Hyslop et al article on "A small sample confidence interval approach to assess individual bioequivalence" (Statistic in Med 2000, 19, pp2885-2897).
I have few questions

How do you calculate the s_int? Based on the Hyslop's paper the subject by formulation interaction is calculated using sig_D, sig_wt, and sig_wr. Is this the way to calculate based on Hyslop et al. paper?
If above statement is correct do we assume sig_wt is equal to sig_wr, as stated by Ekbohm and Melander et al. in "The subject-by-formulation interaction as a criterion for interchangeability of drugs". (Biometrics 1989; 45:1249-1254).
It was my understanding that Reference scaled Average BE is the special case of the IBE where we assume sig_D is negligible and the sig_wt is equal or smaller than the sig_wr. Is this correct?

In advance thank you for your input on the above questions
Kindly
sdu

Complete thread:

Reference scaled approach for HVD KR 2009-02-07 11:29
- Reference scaled approach for HVD Helmut 2009-02-07 15:58
  - Reference scaled approach for HVD d_labes 2009-02-09 11:26
    - Reference scaled approach for HVD ddubins 2009-03-12 03:34
      - Estimated knowledge d_labes 2009-03-12 14:55
        
        Estimated knowledgesdu 2010-01-26 21:21
        
        SABE issues d_labes 2010-01-27 14:00
  - Reference scaled approach for HVD BE 2009-03-19 12:30
- Reference scaled approach for HVD MGR 2009-04-01 07:59