Bioequivalence and Bioavailability Forum • TRT / RTR Design

TRT / RTR Design [RSABE / ABEL]

posted by mittyri – Russia, 2017-05-02 20:38 (3342 d 23:02 ago) – Posting: # 17295
Views: 12,308

Dear Yura,

you should use all data included in PK analysis (ie all subjects) for CI estimation.
To extent the limits you need to calculate variability of RR, that is, 50% of subjects.
A hint: even if you try to calculate variability of RR for overall dataset, the majority of software (at least SAS PHX, R) is smart enough not to include the subjects with one R.

❝ The appropriate sample size must be.

❝ Alpha correction.

what did you mean here?

—
Kind regards,
Mittyri

Complete thread:

TRT / RTR Design Yura 2017-05-01 09:34
- TRT / RTR Designmittyri 2017-05-02 18:38
  - TRT / RTR Design Yura 2017-05-02 21:19
    - TRT / RTR Design Helmut 2017-05-02 22:04
      - TRT / RTR Design Yura 2017-05-03 07:41
        
        TRT / RTR Design Helmut 2017-05-03 21:49
        
        TRT / RTR Design ElMaestro 2017-05-03 22:04
        
        TRT / RTR Design Helmut 2017-05-06 18:33
        
        TRR / RTT Design Yura 2017-05-09 11:35
        
        TRR / RTT Design Helmut 2017-05-09 13:06
        
        TRR / RTT Design Yura 2017-05-09 16:18
        
        TRR / RTT Design Helmut 2017-05-09 16:56
        
        TRR / RTT Design Yura 2017-05-09 17:36
        
        TRR / RTT Design Helmut 2017-05-09 17:53
        
        TRR / RTT Design Yura 2017-05-09 18:07