Bioequivalence and Bioavailability Forum

Dear all,

As we know for NTI drugs guidelines Warfarin has suggested that use both (1) scaled and unscaled ABE, in addition to that (2) calculation of 90% CI of ratio of within subject standard deviation of test to reference product.

here my problem is (2). i don't know how to calculate (2). but i tried it with 'COVPRMS' of 'PROC MIXED' from normal ln transformed data (not from ilat, dlat). i calculated within subject standard deviation for test and reference using 'estimates' in 'COVPRMS'. now i just want to know am i doing it in the correct way or not?

Thanks and Regards,
Satish.