Bioequivalence and Bioavailability Forum

Dear MGR,

❝ As per the above, can we do the sample size in SAS software, if so can we use pairedmeans option in procpower or anything?

Sorry . You have to do the power calculations via simulations because the methods underlying the scaled ABE have no (simple or complicated) analytical solution. And there is no Proc in SAS available to do this out of the box.

In principle the simulations could be programmed in SAS, but IMHO this is a horrible task. Moreover the run-time expected is very slow.
For that reasons (ease of programming, run-time) I had chosen the language R to implement the power/sample size estimation for scaled ABE, also my daily job is struggling with the beast SAS.

R is free available at CRAN, package PowerTOST also.
Both are relative easy to install. See this post.

Thus I recommend you to use that way to be able to do the sample size estimation for scaled ABE.