Bioequivalence and Bioavailability Forum • FDA RSABE & alpha inflation

FDA RSABE & alpha inflation [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2015-02-03 14:41 (3752 d 22:04 ago) – Posting: # 14365
Views: 22,716

Dear Detlew,

❝ That's the knackpunkt: They force us not to look at theta0=0.8 or 1.25 but if s_W>0.25 at exp(+-sW*ln(1.25)/0.25) i.e. at 0.7694922 | 1.299558 if CV=30%. See Fig. 2 and the paragraph "Controversies" of that paper.

❝

❝ And then hokus pokus:

❝ power.RSABE(CV=0.30, n=24, theta0=1.299558, design="2x3x3", nsims=1e6)

❝ [1] 0.048717

Heck, the “implied BE limits”!¹ THX, for reminding me (the 10^th time?)… I think that this is really hokus pokus!² Wish to have more spare-time.

Medieval abbots used to say “Ego te baptizo carpam!” (I christ you carp!) before they ate their roast meat during the Lenten season.
László Endrényi likes your term “hokus pokus”…

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
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Complete thread:

EMA oracle Helmut 2015-01-27 16:27
- EMA oracle nobody 2015-01-27 17:07
- Personal opinion ElMaestro 2015-01-27 17:56
- EMA oracle d_labes 2015-01-27 19:44
  - EMA oracle nobody 2015-01-28 09:04
    - EMA oracle ElMaestro 2015-01-28 13:11
- Response from Alfredo García-Arieta Helmut 2015-01-30 10:55
  - Response from Alfredo García-Arieta nobody 2015-01-30 14:55
    - Wonnemann’s Figure 4 on steroids Helmut 2015-02-01 01:35
      - Wonnemann’s Figure 4 on steroids nobody 2015-02-01 11:18
        
        Wonnemann’s Figure 4 on steroids Helmut 2015-02-01 14:49
      - General remarks ElMaestro 2015-02-01 18:43
        
        General remarks nobody 2015-02-01 22:04
        General remarks Helmut 2015-02-02 00:48
        
        General remarks nobody 2015-02-02 08:09
        
        General remarks Helmut 2015-02-02 14:06
        
        TIE: questions mittyri 2015-02-03 12:44
        
        TIE: questions Helmut 2015-02-03 13:24
        
        FDA RSABE & alpha inflation d_labes 2015-02-03 12:02
        
        FDA RSABE & alpha inflation Helmut 2015-02-03 12:22
        
        FDA RSABE & alpha inflation d_labes 2015-02-03 13:07
        
        FDA RSABE & alpha inflationHelmut 2015-02-03 13:41
- New Zealand nobody 2015-01-31 11:25
  - New Zealand Helmut 2015-02-01 16:08
    - New Zealand nobody 2015-02-01 22:08
      - New Zealand Helmut 2015-02-01 23:54
        
        New Zealand nobody 2015-02-02 08:07