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RegisterGeneral remarks [RSABE / ABEL]
posted by Helmut 
– Vienna, Austria, 2015-02-02 15:06 (4164 d 00:05 ago) – Posting: # 14353
Views: 26,368
Hi nobody,
Scaling depends on the CVw of the reference. If you are able to manufacture a new product with smaller variability you get a reward in sample size (same widening of the AR but tighter CI). Example (T/R 0.9, 80% power, 4-period full replicate):
If you mean that the true CVwR is 25–28% and you observe 31%, yes. You scale the AR to 79.44–125.89% although the reference is not highly variable. Lucky punch for the producer, slightly increased risk for the patient.
❝ So: make your 25-28% something formulation…
Scaling depends on the CVw of the reference. If you are able to manufacture a new product with smaller variability you get a reward in sample size (same widening of the AR but tighter CI). Example (T/R 0.9, 80% power, 4-period full replicate):
CVwR CVwT n
0.35 0.35 34
0.35 0.25 26
❝ …go with 31% in the study and you are on the lucky side of life, hu?
If you mean that the true CVwR is 25–28% and you observe 31%, yes. You scale the AR to 79.44–125.89% although the reference is not highly variable. Lucky punch for the producer, slightly increased risk for the patient.
—
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Helmut Schütz
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Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz
The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes
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