Bioequivalence and Bioavailability Forum • Wonnemann’s Figure 4 on steroids

Wonnemann’s Figure 4 on steroids [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2015-02-01 15:49 (4164 d 08:52 ago) – Posting: # 14337
Views: 26,900

Hi nobody,

❝ Hi Mr. Schütz (still have your stocks :-D )

Wow. Didn’t know that I issued some.

❝ […] What do you mean when you write:

❝ "...Therefore, the labeling of the y-axis is not unfortunate."

Dammit, at leftover from editing. Should read “… labeling of the y-axis is ~~not~~ unfortunate.” Since they looked at GMR 1.25 they shouldn’t call if TIE for any CV_wR >30%.

I updated the plots. The solid black line is at 0.05 and the dotted red line at the significance limit for 10⁶ simulations (0.05036). Blue circles are ≤0.05036 and red circles >0.05036.

We must not be concerned about the TIE if the CV_WR is rather high (40ish).
There is inflation of the TIE even for “true” CV_wR ≤30%. Counterintuitive first, but a consequence of the data-driven decision. If the true (but unknown) CV_wR ≤30%, in a certain fraction of studies we falsely apply scaling (based on the observed CV_wR >30%). At 30% the chance for such a wrong decision is 50:50. Therefore, we can expect the highest inflation of the TIE at 30%.

—
Dif-tor heh smusma 🖖🏼 Довге життя Україна!
Helmut Schütz

The quality of responses received is directly proportional to the quality of the question asked. 🚮
Science Quotes

Complete thread:

EMA oracle Helmut 2015-01-27 16:27
- EMA oracle nobody 2015-01-27 17:07
- Personal opinion ElMaestro 2015-01-27 17:56
- EMA oracle d_labes 2015-01-27 19:44
  - EMA oracle nobody 2015-01-28 09:04
    - EMA oracle ElMaestro 2015-01-28 13:11
- Response from Alfredo García-Arieta Helmut 2015-01-30 10:55
  - Response from Alfredo García-Arieta nobody 2015-01-30 14:55
    - Wonnemann’s Figure 4 on steroids Helmut 2015-02-01 01:35
      - Wonnemann’s Figure 4 on steroids nobody 2015-02-01 11:18
        
        Wonnemann’s Figure 4 on steroidsHelmut 2015-02-01 14:49
      - General remarks ElMaestro 2015-02-01 18:43
        
        General remarks nobody 2015-02-01 22:04
        General remarks Helmut 2015-02-02 00:48
        
        General remarks nobody 2015-02-02 08:09
        
        General remarks Helmut 2015-02-02 14:06
        
        TIE: questions mittyri 2015-02-03 12:44
        
        TIE: questions Helmut 2015-02-03 13:24
        
        FDA RSABE & alpha inflation d_labes 2015-02-03 12:02
        
        FDA RSABE & alpha inflation Helmut 2015-02-03 12:22
        
        FDA RSABE & alpha inflation d_labes 2015-02-03 13:07
        
        FDA RSABE & alpha inflation Helmut 2015-02-03 13:41
- New Zealand nobody 2015-01-31 11:25
  - New Zealand Helmut 2015-02-01 16:08
    - New Zealand nobody 2015-02-01 22:08
      - New Zealand Helmut 2015-02-01 23:54
        
        New Zealand nobody 2015-02-02 08:07