Bioequivalence and Bioavailability Forum • 3x3 or 2x4?

3x3 or 2x4? [RSABE / ABEL]

posted by felipeberlinski – Brazil, 2014-10-22 16:20 (4265 d 19:28 ago) – Posting: # 13763
Views: 19,009

Dear friends

Reading a BE reccomendation of FDA I would like to know about your experience using two different designs.

Since the drug is a HVD:
Their reccomendation is to use a 3-sequence 3-period or a 2-sequence 4 period design.

Could anybody explain the main differences between them and when should I use each one? Go easy, I'm not a biostatistician :cool:

Thanks in advance

Edit: Category changed. [Helmut]

Complete thread:

3x3 or 2x4?felipeberlinski 2014-10-22 14:20
- 3x3 or 2x4? ElMaestro 2014-10-22 14:42
  - 3x3 or 2x4? nobody 2014-10-22 15:06
    - 3x3 or 2x4? felipeberlinski 2014-10-22 15:36
      - 3x3 or 2x4? nobody 2014-10-22 15:41
      - 2x3x3 or 2x2x3 or 2x2x4? d_labes 2014-10-22 16:12
        
        2x3x3 or 2x2x3 or 2x2x4? MGR 2015-04-08 13:35
        
        Sample size for scABE in SAS? d_labes 2015-04-08 16:06
        Re-inventing the wheel Helmut 2015-04-08 16:19
- RTR|TRT Helmut 2014-10-22 16:36
- 3x3 or 2x4? Mauricio Sampaio 2014-10-28 12:12