Bioequivalence and Bioavailability Forum • Arbitrary smoothing?

Arbitrary smoothing? [RSABE / ABEL]

posted by d_labes – Berlin, Germany, 2014-07-22 10:43 (4360 d 08:47 ago) – Posting: # 13289
Views: 15,449

Dear Helmut,

❝ A lot of ‘noise’, but essentially I could reproduce the reported inflation (converging at ~7.5%). Inflation with this method is a textbook example (unadjusted multiple testing). I’m happy that finally someone demonstrated it. The inflation is what to expect from pooling two groups, where the size of the second one is 50% of the first: 0.05+0.05/2=0.075… Voilà.

Where does the tremendous noise in your pictures came from?

And Fig. 2 (as well as others) of the paper is with tremendous (arbitrary?) smoothing? Crossing of some of the curves seems to point in that direction. The plot form (continuous curves, without the points they have simulated) itself is suspicious IMHO.

BTW: Do you see any need to create a power.addon() in PowerTOST? Pedagogical?

—
Regards,

Detlew

Complete thread:

EMA: α-inflation – the suspicion begins to mount Helmut 2014-07-21 02:04
- EMA: α-inflation – the suspicion begins to mount ElMaestro 2014-07-21 09:24
  - Why simulate a simple AB|BA at all? Helmut 2014-07-21 16:14
    - Why simulate a simple AB|BA at all? ElMaestro 2014-07-21 20:50
      - Fancy smoothing? Helmut 2014-07-21 23:13
        
        Arbitrary smoothing?d_labes 2014-07-22 08:43
        
        Noise… Helmut 2014-07-22 13:31
        
        TSD Japonica… d_labes 2014-07-22 16:06
        
        TSD Japonica… Helmut 2014-07-22 17:50
        
        Noise debugged d_labes 2014-07-24 13:47
        
        Noise debugged Helmut 2014-07-24 15:07
        
        Shit happens d_labes 2014-07-24 16:09
      - Commentary d_labes 2014-07-22 08:18
        
        Commentary nobody 2014-09-15 08:24
        
        Commentary Helmut 2014-09-15 10:12
      - IBE/PBE = Two-Stage Helmut 2014-09-29 03:33
        
        IBE/PBE = Two-Stage ElMaestro 2014-09-29 15:16
        
        Sequential Design = Inflation likely… Helmut 2014-09-30 15:03