Bioequivalence and Bioavailability Forum

scABE - implied limits [RSABE / ABEL]

posted by d_labes  – Berlin, Germany, 2014-03-31 13:16 (4475 d 05:47 ago) – Posting: # 12743
Views: 3,896

Dear Angus,

❝ I am reading the review paper of Barbara Davit published in Pharm. Research 2013. I have a comprehension problem ...

From time to time I also suffer from those symptoms .

❝ ... Ln (1.25) σWR/σ W0

❝ As I read this equation I am thinking it is Ln(1.25)0.7565/0.25 =0.223*0.7565/0.25 = 0.6747

This is correct AFAIK with the exception
[nitpicking]log(1.25)*0.7565/0.25=0.6752324[/nitpicking]

But the implied limits (lower limit is -0.6752324) are in the log domain. To obtain them in the original scale back-transform them
exp(-0.6752324)=0.5090381 (50.9%)
exp( 0.6752324)=1.964489 (196.4%)

Complete thread:

• Reference-scaled Bioequivalence AngusMcLean 2014-03-28 17:48 
  • scABE - implied limitsd_labes 2014-03-31 11:16