Bioequivalence and Bioavailability Forum • Carry-over

Carry-over [RSABE / ABEL]

posted by Helmut – Vienna, Austria, 2014-02-07 18:12 (4113 d 10:23 ago) – Posting: # 12370
Views: 17,296

Hi Lucas!

❝ ❝ For the 2x2x4 design the PASS calculations are moreover based on a model including carry-over. In today's time no one will use such an model.

❝

❝ I'm sorry, but we may be a little outdated down here then. We do include carry-over in our replicate studies.

May I ask which code you are using?

❝ Where can I find more info about that to update our knowledge?

Well, this goody…

S Senn
Cross-over Trials in Clinical Research
John Wiley & Sons, Chichester (2^nd ed 2002)
ISBN: 978-0-471-49653-3

…is essentially an essay against carry-over. If there is a true sequence effect (or more precisely unequal carry-over) you can’t do anything in the analysis. The treatment estimates will be biased. Since there is no method to deal with carry-over, the only option we have is to avoid it by design, i.e., sufficiently long wash-out periods.
You will find some stuff (and linked references) in the forum.

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Complete thread:

Sample size calculation for R-SABE Lucas 2014-02-07 11:41
- EMA’s ABEL Helmut 2014-02-07 14:21
  - EMA’s ABEL Lucas 2014-02-07 16:49
    - Carry-overHelmut 2014-02-07 17:12
      - Carry-over Lucas 2014-02-07 17:42
        
        Carry-over Shuanghe 2014-02-10 17:11
- PowerTOST and Sample size estimation for R-SABE d_labes 2014-02-07 14:37
  - PowerTOST and Sample size estimation for R-SABE kumarnaidu 2014-04-18 13:38
    - PowerTOST and Sample size estimation for R-SABE Dr_Dan 2014-04-18 19:29
      - PowerTOST and Sample size estimation for R-SABE kumarnaidu 2014-04-19 06:04
  - PowerTOST and Sample size estimation for R-SABE Astea 2015-06-25 01:14
    - Sample size for scABEL/RSABE vs. conventional ABE d_labes 2015-06-25 09:19
    - PowerTOST and Sample size estimation for R-SABE mittyri 2015-06-25 10:43
      - PowerTOST and Sample size estimation for R-SABE Astea 2015-06-25 13:54
        
        Scaled ABE d_labes 2015-06-25 14:04