Bioequivalence and Bioavailability Forum

RR values only [RSABE / ABEL]

posted by Yvonne – 2013-10-23 17:20 (4221 d 07:38 ago) – Posting: # 11737
Views: 7,333

Dear Detlew and Helmut

❝ On the other hand I cant imagine a random process for a fully replicate design where f.i. in sequence TRTR the subject absolved 2nd and fourth period, but no 1st and third period. Seems very unlikely to me.

No indeed, but a sequence with RTRT, no 2nd and 4th period seems possible to me. This would generate two R periods and no T periods....

❝ Haven’t seen that in the wild. Only EMA (in their Q&A document) fabricates such data.

I have seen "in the wild" a first and fourth period

❝ @Yvonne: What happened in the study? Was it a fully replicated design (as Detlew assumed)?

Currently I am writing a protocol (fully replicate) and thinking about possible theoretic cases.... (I'm sorry, not that exciting unfortunately...).

Complete thread:

• Fully Replicated design sirajudeen 2013-09-24 07:00 
  • Fully Replicated design Dr_Dan 2013-09-24 11:17
    • Fully Replicated design Yvonne 2013-10-14 09:39
      • RR values only Helmut 2013-10-14 17:28
        • RR values only d_labes 2013-10-14 18:38
          • RR values only Helmut 2013-10-14 19:21
            • RR values onlyYvonne 2013-10-23 15:20
              • RR values only Helmut 2013-10-23 17:51
                • RR values only Yvonne 2013-10-24 09:01