Bioequivalence and Bioavailability Forum • Partial replicate designs

Partial replicate designs [RSABE / ABEL]

posted by The Outlaw Torn – Europe, 2013-09-25 13:10 (4660 d 17:38 ago) – Posting: # 11558
Views: 6,667

Hello again,

❝ First, the partial replicate is TRR|RTR|RRT – which is a lousy design. I would opt for a full replicate with three periods (RTR|TRT). Similar sample size/costs, more information.

Don't mean to interupt your "vacation" in beautiful Jordan, but if you have "nothing better to do--it's not like they have good falafels or kebabs there" :hungry:

mind explaining why it's a lousy design?

❝ ❝ The second thing is the following. What is the sample size estimate for a drug (not Schützomycin) with a intra-subject variability of 37.5%? And how would those subjects be distributed per group in said partial replicate?

So, only 15 or 16 subjects per groups, eh? Hmmmm. Would have expected more. I'll have to do a bit more head wrapping and may have a follow-up.

Thanks for everything. And enjoy Amman.

Take care,
Outlaw Torn

Complete thread:

Partial replicate designs The Outlaw Torn 2013-09-25 08:21
- Partial replicate designs Helmut 2013-09-25 09:12
  - Partial replicate designsThe Outlaw Torn 2013-09-25 11:10
    - Partial replicate designs Helmut 2013-09-25 16:35
      - Partial replicate designs The Outlaw Torn 2013-09-26 08:34
        
        OT Helmut 2013-09-26 08:56