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Registerfully replicate design with four sequence [RSABE / ABEL]
Hi Helmut,
On reviewing the data of four period two sequence (ABAB and BABA) fully replicated study retrospectively, there is a statistically significant period effect reported for Cmax. So would like to know whether we can use four period four sequence fully replicated study to nullify this period effect which is described in the FDA guideline (Appendix B- Reasons Unrelated to Carryover Effects).
regards
RK
On reviewing the data of four period two sequence (ABAB and BABA) fully replicated study retrospectively, there is a statistically significant period effect reported for Cmax. So would like to know whether we can use four period four sequence fully replicated study to nullify this period effect which is described in the FDA guideline (Appendix B- Reasons Unrelated to Carryover Effects).
regards
RK
Complete thread:
- fully replicate design with six sequences RK 2013-09-14 12:17
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Objective? Helmut 2013-09-15 13:47
- Objective? jag009 2013-09-16 17:24
- Objective? RK 2013-09-17 13:35
- Objective? (again) Helmut 2013-09-17 13:51
- Question: jag009 2013-09-17 15:49
- Imbalanced/incomplete sequences Helmut 2013-09-18 17:32
- fully replicate design with four sequenceRK 2013-09-20 13:56
- Period effects and sequences unrelated d_labes 2013-09-23 08:44
- Period effects and sequences unrelated RK 2013-09-24 13:16
- Period effects and sequences unrelated d_labes 2013-09-23 08:44
- Question: jag009 2013-09-17 15:49
- Objective? (again) Helmut 2013-09-17 13:51
- Objective? Helmut 2013-09-15 13:47
Ing. Helmut Schütz