Bioequivalence and Bioavailability Forum

Imbalanced/incomplete sequences [RSABE / ABEL]

posted by Helmut  – Vienna, Austria, 2013-09-18 19:32 (4256 d 02:35 ago) – Posting: # 11520
Views: 7,802

Hi John,

❝ Missing observations ⇒ Does that mean we would encounter problems if not all subjects have data for each treatment? i.e, what if we miss some AUCinf values when kel cannot be determined?

There might be a small bias. However, sequences would have to be extremely imbalanced/incomplete to start hurting. Look at FDA’s replicate example data sets.
n_AUC∞ ≠ n_AUCt is rather a rule than an exception.

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Helmut Schütz


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Science Quotes

Complete thread:

• fully replicate design with six sequences RK 2013-09-14 12:17 
  • Objective? Helmut 2013-09-15 13:47
    • Objective? jag009 2013-09-16 17:24
    • Objective? RK 2013-09-17 13:35
      • Objective? (again) Helmut 2013-09-17 13:51
        • Question: jag009 2013-09-17 15:49
          • Imbalanced/incomplete sequencesHelmut 2013-09-18 17:32
        • fully replicate design with four sequence RK 2013-09-20 13:56
          • Period effects and sequences unrelated d_labes 2013-09-23 08:44
            • Period effects and sequences unrelated RK 2013-09-24 13:16