Bioequivalence and Bioavailability Forum • CI calculation in full replicate design

CI calculation in full replicate design [RSABE / ABEL]

posted by jag009 – NJ, 2013-06-03 22:06 (4363 d 00:17 ago) – Posting: # 10721
Views: 4,868

Hi Ken,

❝ May I know how to calculate the 90% Confidence Interval (CI) for AUC and Cmax in a fully replicate design of 2x2x4 for highly variable drug ? We follow the progesterone method proposed by FDA and calculate to the last step of point estimate. However, we are not sure how to calculate the 90% CI.

I tried the code and it worked(sample data). Did you check Helmut's post about the FDA progesterone guidance pdf having missing SAS codes(due to the font color or something)?

John

Complete thread:

CI calculation in full replicate design Ken Peh 2013-06-03 19:11
- CI calculation in full replicate designjag009 2013-06-03 20:06
  - CI calculation in full replicate design Ken Peh 2013-06-05 12:43
    - CI not needed in RSABE Helmut 2013-06-05 13:40
      - CI not needed in RSABE Ken Peh 2013-06-05 17:31
    - CI calculation in full replicate design jag009 2013-06-05 19:56