Bioequivalence and Bioavailability Forum • CI calculation in full replicate design

CI calculation in full replicate design [RSABE / ABEL]

posted by Ken Peh – Malaysia, 2013-06-03 21:11 (4774 d 13:41 ago) – Posting: # 10720
Views: 7,303

Dear All,

May I know how to calculate the 90% Confidence Interval (CI) for AUC and Cmax in a fully replicate design of 2x2x4 for highly variable drug ?

We follow the progesterone method proposed by FDA and calculate to the last step of point estimate. However, we are not sure how to calculate the 90% CI.

Your input is highly appreciated.

Thank you.

Regards,
Ken

Edit: Category changed. [Helmut]

Complete thread:

CI calculation in full replicate designKen Peh 2013-06-03 19:11
- CI calculation in full replicate design jag009 2013-06-03 20:06
  - CI calculation in full replicate design Ken Peh 2013-06-05 12:43
    - CI not needed in RSABE Helmut 2013-06-05 13:40
      - CI not needed in RSABE Ken Peh 2013-06-05 17:31
    - CI calculation in full replicate design jag009 2013-06-05 19:56