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RegisterCI calculation in full replicate design [RSABE / ABEL]
Dear All,
May I know how to calculate the 90% Confidence Interval (CI) for AUC and Cmax in a fully replicate design of 2x2x4 for highly variable drug ?
We follow the progesterone method proposed by FDA and calculate to the last step of point estimate. However, we are not sure how to calculate the 90% CI.
Your input is highly appreciated.
Thank you.
Regards,
Ken
Edit: Category changed. [Helmut]
May I know how to calculate the 90% Confidence Interval (CI) for AUC and Cmax in a fully replicate design of 2x2x4 for highly variable drug ?
We follow the progesterone method proposed by FDA and calculate to the last step of point estimate. However, we are not sure how to calculate the 90% CI.
Your input is highly appreciated.
Thank you.
Regards,
Ken
Edit: Category changed. [Helmut]
Complete thread:
- CI calculation in full replicate designKen Peh 2013-06-03 19:11
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- CI calculation in full replicate design jag009 2013-06-03 20:06
- CI calculation in full replicate design Ken Peh 2013-06-05 12:43
- CI not needed in RSABE Helmut 2013-06-05 13:40
- CI not needed in RSABE Ken Peh 2013-06-05 17:31
- CI calculation in full replicate design jag009 2013-06-05 19:56
- CI not needed in RSABE Helmut 2013-06-05 13:40
- CI calculation in full replicate design Ken Peh 2013-06-05 12:43
- CI calculation in full replicate design jag009 2013-06-03 20:06
Ing. Helmut Schütz