Log in
RegisterNut Job.. [RSABE / ABEL]
Hi everyone,
Continuing the sage... I now have full dataset and I included AUCt as well.
Once again using the ABE procedure with Proc Mixed from FDA progesterone guidance. I was fine with ln AUCt but did get a message in the SAS log:
NOTE: Convergence criteria met but final hessian is not positive definite.
NOTE: Asymptotic variance matrix of covariance parameter estimates has been found to be singular and a generalized inverse was used. Covariance parameters with zero variance do not contribute to degrees of freedom computed by DDFM=SATTERTH.
For AUCt
Ratio: 94.7377; 90% CI: 87.4898-102.586
However, Proc Mixed failed to compute the above for ln AUCi and gave me a warning message in SAS log:
WARNING: Did not converge.
WARNING: Output 'Estimates' was not created....
The last output from Proc Mixed on ln AUCi was:
I used the same ABE SAS Code posted in the first message in this thread (and the codes are the same for AUCt and AUCi).
The Dataset:
Subject, Sequence, Period, Treatment, ln AUCt, ln AUCi.
Sequence: ABB = 1, BAB = 2, BBA = 3
Any idea?
Thanks
John
Continuing the sage... I now have full dataset and I included AUCt as well.
Once again using the ABE procedure with Proc Mixed from FDA progesterone guidance. I was fine with ln AUCt but did get a message in the SAS log:
NOTE: Convergence criteria met but final hessian is not positive definite.
NOTE: Asymptotic variance matrix of covariance parameter estimates has been found to be singular and a generalized inverse was used. Covariance parameters with zero variance do not contribute to degrees of freedom computed by DDFM=SATTERTH.
For AUCt
Ratio: 94.7377; 90% CI: 87.4898-102.586
However, Proc Mixed failed to compute the above for ln AUCi and gave me a warning message in SAS log:
WARNING: Did not converge.
WARNING: Output 'Estimates' was not created....
The last output from Proc Mixed on ln AUCi was:
Covariance Parameter Values At Last Iteration
Cov Parm Subject Group Estimate
FA(1,1) subject 0.3722
FA(2,1) subject 0.3975
FA(2,2) subject 0.2362
Residual subject formulation Ref 0.06248
Residual subject formulation Test 0.01460I used the same ABE SAS Code posted in the first message in this thread (and the codes are the same for AUCt and AUCi).
The Dataset:
Subject, Sequence, Period, Treatment, ln AUCt, ln AUCi.
Sequence: ABB = 1, BAB = 2, BBA = 3
1 BBA 3 A 7.392949199 7.966255738
2 ABB 1 A 7.486969192 7.642465619
3 BAB 2 A 7.795040591 7.900675886
4 ABB 1 A 7.704527971 7.810454463
5 BBA 3 A 7.74341453 7.813019037
6 BAB 2 A 8.862899236 8.887092743
7 BBA 3 A 7.474575339 7.520470843
8 ABB 1 A 6.649783454 6.786800469
9 BAB 2 A 7.900081068 7.917934089
10 BAB 2 A 8.498478152 8.537308319
11 BBA 3 A 7.687297563 7.764432727
12 ABB 1 A 7.854077711 8.056187995
14 BAB 2 A 6.834931866 7.311990298
15 BBA 3 A 8.004066923 8.015037211
17 ABB 1 A 7.954169654 8.081352274
18 BAB 2 A 8.813960369 8.878784152
19 ABB 1 A 7.936215453 8.005634299
20 BAB 2 A 7.585678156 7.624085152
21 BBA 3 A 7.882511503 7.908029742
23 BAB 2 A 7.252320394 7.329537863
25 BAB 2 A 7.460390761 7.612326456
26 BBA 3 A 7.519507463 7.544075461
27 ABB 1 A 7.842873653 7.906903707
28 BBA 3 A 7.974813947 8.117347067
29 ABB 1 A 7.952082082 8.030115018
30 BAB 2 A 6.969401496 7.626733448
31 BBA 3 A 7.375110404 7.425354311
32 ABB 1 A 7.854046269 7.909554125
33 BAB 2 A 8.180100682 8.240037917
34 BBA 3 A 8.498685373 8.50785008
35 BAB 2 A 7.689511601 7.753216597
36 ABB 1 A 7.697065912 7.731297188
37 BAB 2 A 7.743985836 7.768691851
38 BBA 3 A 8.860378559 8.90071176
39 ABB 1 A 7.649143902 7.760258994
40 BBA 3 A 8.178085044 8.269703924
42 ABB 1 A 7.699680257 8.477479957
44 ABB 1 A 8.469052606 8.546889654
45 BBA 3 A 8.734765894 8.773995092
46 ABB 1 A 7.438072894 7.502691878
47 BBA 3 A 7.70220194 7.870368371
48 BAB 2 A 8.326805753 8.371119472
49 BAB 2 A 8.23649812 8.251025744
51 ABB 1 A 8.89042446 8.926528534
52 BBA 3 A 8.319488803 8.645876426
53 ABB 1 A 8.254585577 8.26745589
54 BAB 2 A 8.774547697 8.830803941
55 BBA 3 A 7.695208954 7.75602795
56 BAB 2 A 8.088395381 8.173364805
57 ABB 1 A 7.721135381 7.754655632
59 BAB 2 A 7.624704432 7.649123891
1 BBA 1 B 7.918112873 7.956429845
1 BBA 2 B 8.165388938 8.236181092
2 ABB 2 B 7.648429922 7.840311803
2 ABB 3 B 7.767760063 7.99990909
3 BAB 1 B 7.84509492 7.903718188
3 BAB 3 B 7.004410917 7.201138817
4 ABB 2 B 8.273957131 8.299682496
4 ABB 3 B 7.893447812 7.922782677
5 BBA 1 B 7.873074242 7.993014477
5 BBA 2 B 7.928661129 7.973013452
6 BAB 1 B 8.953187117 9.070644877
6 BAB 3 B 8.620163052 8.635798822
7 BBA 1 B 7.733732169 7.925830821
7 BBA 2 B 7.883843938 7.915115941
8 ABB 2 B 7.040298183 7.138905094
8 ABB 3 B 6.455060189 6.919911097
9 BAB 1 B 8.246138252 8.302636666
9 BAB 3 B 8.369926761 8.407009731
10 BAB 1 B 8.854970576 8.867276941
10 BAB 3 B 8.985634977 9.003601402
11 BBA 1 B 8.178239438 8.255348312
11 BBA 2 B 8.286612805 8.339918637
12 ABB 2 B 8.240486403 8.305583617
12 ABB 3 B 7.800706552 7.826649818
14 BAB 1 B 7.553067914 7.897693791
14 BAB 3 B 7.105642559 7.345723072
15 BBA 1 B 8.238080695 8.313684606
15 BBA 2 B 8.446723945 8.453986902
17 ABB 2 B 6.918289598 8.123267843
17 ABB 3 B 7.238486783 7.484658489
18 BAB 1 B 8.00908587 8.197899082
18 BAB 3 B 7.76105637 7.935726911
19 ABB 2 B 8.102567049 8.141680789
19 ABB 3 B 7.693701307 7.710909115
20 BAB 1 B 8.263957891 8.29405139
20 BAB 3 B 8.174826537 8.190936874
21 BBA 1 B 8.120727864 8.167847324
21 BBA 2 B 7.93456468 8.013054162
23 BAB 1 B 7.358441651 7.473058861
23 BAB 3 B 7.48803103 7.535879021
25 BAB 1 B 7.602494691 7.697937968
25 BAB 3 B 7.387379977 7.469852557
26 BBA 1 B 8.329193303 8.344287565
26 BBA 2 B 8.037593588 8.060771153
27 ABB 2 B 7.905330655 7.935414562
27 ABB 3 B 8.082943041 8.29080137
28 BBA 1 B 7.738586593 7.774590185
28 BBA 2 B 7.859365663 7.889316764
29 ABB 2 B 7.888838125 8.04080281
29 ABB 3 B 7.779364076 7.821842385
30 BAB 1 B 6.982335711 7.543216142
30 BAB 3 B 6.697153994 6.829441243
31 BBA 1 B 7.747856304 7.809290887
31 BBA 2 B 7.560504854 7.797942664
32 ABB 2 B 7.759783505 7.817275946
32 ABB 3 B 7.356405667 7.515982167
33 BAB 1 B 8.36886463 8.379766221
33 BAB 3 B 8.216466676 8.276196466
34 BBA 1 B 8.258608715 8.287758895
34 BBA 2 B 7.998750632 8.069192434
35 BAB 1 B 7.574446055 7.644724111
35 BAB 3 B 7.149663272 7.258526933
36 ABB 2 B 8.2490222 8.258958847
36 ABB 3 B 7.327066091 7.5359057
37 BAB 1 B 8.139238284 8.195958196
37 BAB 3 B 7.634118159 7.675717682
38 BBA 1 B 8.444112046 8.468275809
38 BBA 2 B 8.725257703 8.835573174
39 ABB 2 B 7.265019149 7.428235744
39 ABB 3 B 7.08341721 7.144682596
40 BBA 1 B 8.089394434 8.723463832
40 BBA 2 B 8.21551415 8.256136432
42 ABB 2 B 7.876135868 8.032802077
42 ABB 3 B 7.828881103 7.976931205
44 ABB 2 B 8.410692915 8.428963108
44 ABB 3 B 8.589966402 8.605777165
45 BBA 1 B 8.525890857 8.539325065
45 BBA 2 B 8.458267051 8.472018404
46 ABB 2 B 7.296383438 7.439829543
46 ABB 3 B 7.502625684 8.280353272
47 BBA 1 B 8.195452589 8.244132241
47 BBA 2 B 8.349083368 8.362756337
48 BAB 1 B 8.176094027 8.20568553
48 BAB 3 B 7.815589152 7.870187719
49 BAB 1 B 8.186195741 8.24090015
49 BAB 3 B 8.046571451 8.140032993
51 ABB 2 B 9.073040287 9.097873779
51 ABB 3 B 9.039707436 9.101568489
52 BBA 1 B 7.856079031 7.917417221
52 BBA 2 B 8.921983405 8.936348427
53 ABB 2 B 8.04764098 8.076713878
53 ABB 3 B 8.439900183 8.497614983
54 BAB 1 B 8.082637012 8.110054083
54 BAB 3 B 8.632410093 8.658085799
55 BBA 1 B 8.226321237 8.316787172
55 BBA 2 B 8.105905766 8.171993299
56 BAB 1 B 8.215087328 8.369842175
56 BAB 3 B 7.985378156 8.083406692
57 ABB 2 B 7.86516185 7.899924985
57 ABB 3 B 7.706186822 7.809824158
59 BAB 1 B 7.77147021 7.842954906
59 BAB 3 B 7.423932557 7.452101942Any idea?
Thanks
John
Complete thread:
- FDA's HVD SAS Code from Progesterone Guidance jag009 2013-04-22 16:39
![[Mix]](https://static.bebac.at/img/mix.png "open in Mix view")
- Proc MIXED vs. Proc GLM Helmut 2013-04-22 17:47
- Proc MIXED vs. Proc GLM jag009 2013-04-22 20:33
- SAS vs. PHX Helmut 2013-04-22 22:10
- SAS vs. PHX Shuanghe 2013-04-23 11:45
- SAS vs. SAS d_labes 2013-04-23 16:50
- SAS vs. SAS vs. Phoenix Helmut 2019-11-12 13:01
- SAS vs. SAS d_labes 2013-04-23 16:50
- SAS vs. PHX jag009 2013-04-23 15:56
- SAS Warning (Note) on Proc Mixed jag009 2013-04-23 17:07
- Nut Job..jag009 2013-04-30 21:09
- Second opinion (PHX 6.3) Helmut 2013-05-01 16:21
- Second opinion (PHX 6.3) jag009 2013-05-01 17:16
- Second opinion (PHX 6.3) ElMaestro 2013-05-01 18:48
- In praise of a full replicate Helmut 2013-05-01 19:16
- Third opinion d_labes 2013-05-02 12:00
- Compound Symmetry Helmut 2013-05-02 14:41
- Compound Symmetry - SASian (1) d_labes 2013-05-02 16:26
- Variance=0 Helmut 2013-05-03 16:07
- Compound Symmetry - SASian (1) d_labes 2013-05-02 16:26
- Compound Symmetry Helmut 2013-05-02 14:41
- Second opinion (PHX 6.3) jag009 2013-05-01 17:16
- Second opinion (PHX 6.3) Helmut 2013-05-01 16:21
- Nut Job..jag009 2013-04-30 21:09
- SAS Warning (Note) on Proc Mixed jag009 2013-04-23 17:07
- SAS vs. PHX Shuanghe 2013-04-23 11:45
- SAS vs. PHX Helmut 2013-04-22 22:10
- Proc MIXED vs. Proc GLM jag009 2013-04-22 20:33
- Proc MIXED vs. Proc GLM Helmut 2013-04-22 17:47
Ing. Helmut Schütz